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Literatur und weiterführende Links (FOOD 18-21)


Literaturliste zu Chrom

Althuis MD, Jordan NE, Ludington EA, Wittes JT: Glucose and insulin responses to dietary chromium supplements: a meta-analysis. Am J Clin Nutr 2002; 76: 148–155.

Anderson RA et al. Lack of toxicity of chromium chloride and chromium picolinate in rats. J Am Coll Nutr 1997; 16: 273–279.

Anderson RA, Kozlovsky AS. Chromium intake, absorption, and excretion of subjects consuming selfselected diets. Am J Clin Nutr 1985, 41: 1177–1183.

Anderson RA: Effects of chromium on body composition and weight loss. Nutr Rev 1998;56:266–270.

Bagchi D, Stohs SJ, Downs BW, Bagchi M, Preuss HG: Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology 2002;180:5–22.

Bahadori B et al. Effects of chromium yeast and chromium picolinate on body composition in obese non-diabetic patients during and after a very-low-calorie diet. Acta Med Austriaca 1997; 24: 185–187.

Bahijri SM, Mufti AM. Beneficial effects of chromium in people with type 2 diabetes, and urinary chromium response to glucose load as a possible indicator of status. Biol Trace Elem Res 2002; 85: 97–109.

Balk EM et al. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care 2007; 30: 2154–2163.

Bartlett HE, Eperjesi F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt 2008; 28: 503–523.

Bennett R et al. High-dose chromium(III) supplementation has no effects on body mass and composition while altering plasma hormone and triglycerides concentrations. Biol Trace Elem Res 2006; 113: 53–66.

Blasiak J, Kowalik J. A comparison of the in vitro genotoxicity of tri- and hexavalent chromium. Mutat Res. 2000;469:135-145.

Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus–a review. Diabetes Technol Ther. 2006;8:677-687.

Bulbulian R et al. Chromium picolinate supplementation in male and female swimmers. Med Sci Sports Exerc 1996; 28 (Suppl.): 111.

Campbell WW, Beard JL, Joseph LJ, Davey SL, Evans WJ. Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes. Am J Clin Nutr. 1997;66:944-949.

Cefalu WT, Hu FB (2004) Role of chromium in human health and in diabetes. Diabetes Care 27:2741–2751.

Cerulli J, Grabe DW, Gauthier I, Malone M, McGoldrick MD. Chromium picolinate toxicity. Ann Pharmacother. 1998;32:428-431.

Chen G, Liu P, Pattar GR, et al. Chromium activates glucose transporter 4 trafficking and enhances insulin-stimulated glucose transport in 3T3-L1 adipocytes via a cholesterol-dependent mechanism. Mol Endocrinol. 2006;20:857-870.

Cheng HH, Lai MH, Hou WC, Huang CL: Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. J Agric Food Chem 2004;52:1385–1389.

Clausen J. Chromium induced clinical improvement in symptomatic hypoglycemia. Biol Trace Elem Res 1988; 17: 229–236.

Dietary Reference Intakes: Chromium. In: A Report of the Panel of Micronutritients, Subcommittees on Upper Reference Levels of Nutritients and of the Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Ed. Food and Nutrition Board, Institute of Medicine, pp. 197– 223. National Academy Press, Washington DC, 2001

Gunton JE, Hams G, Hitchman R, McElduff A. Serum chromium does not predict glucose tolerance in late pregnancy. Am J Clin Nutr. 2001;73:99-104.

Hasten DL et al. Effects of chromium picolinate on beginning weight training students. Int J Sport Nutr 1992; 2: 343–350.

Hellerstein MK. Is chromium supplementation effective in managing type II diabetes? Nutr Rev. 1998;56:302-306.

Hermann J, Arquitt A, Stoecker B: Effects of chromium supplementation on plasma lipids, apolipoproteins and glucose in elderly subjects. Nutr Res 1994; 671–674.

Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg GR, Bruce-Robertson A: Chromium deficiency, glucose intolerance and neuropathy reversed by chromium supplementation in a patient receiving long-term parenteral nutrition. Am J Clin Nutr 1977; 30: 531–538.

Kleefstra N et al. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2007; 30: 1092–1096.

Kobla HV, Volpe SL. Chromium, exercise, and body composition. Crit Rev Food Sci Nutr. 2000;40:291-308.

Livolsi JM et al. The effect of chromium picolinate on muscular strength and body composition in women athletes. J Strength Cond Res 2001; 15: 161–166.

Lukaski HC, Siders WA, Penland JG: Chromium picolinate supplementation in women: effects on body weight, composition, and iron status. Nutrition 2007; 23 (3): 187–195.

Lukaski HC, Bolonchuk WW, Siders WA, Milne DB. Chromium supplementation and resistance training: effects on body composition, strength, and trace element status of men. Am J Clin Nutr. 1996;63:954-965.

Lukaski HC. Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr. 2000;72(2 Suppl):585S-593S.

Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 2006;29:1826-1832.

Mertz W. Chromium in human nutrition: a review. J Nutr. 1993;123:626-633.

Milne DB: Laboratory assessment of trace element and mineral status. In: Clinical Nutrition of the Essential Trace Elements and Minerals. Ed. Bogden JD, Kleavy LM, 2000, pp. 69– 90. Humana Press, Totowa, New Jersey

Mooney KW, Cromwell GL. Effects of dietary chromium picolinate supplementation on growth, carcass characteristics, and accretion rates of carcass tissues in growing-finishing swine. J Anim Sci 1995; 73 : 3351–3357.

Pattar GR, Tackett L, Liu P, Elmendorf JS. Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions. Mutat Res. 2006;610:93-100.

Pittler MH, Stevinson C, Ernst E. Chromium picolinate for reducing body weight: meta-analysis of randomized trials. Int J Obes Relat Metab Disord. 2003;27:522-529.

Rabinovitz H et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004; 74: 178–182.

Ravina A, Slezak L, Rubal A, Mirsky N: Clinical use of the trace element chromium (III) in the treatment of diabetes mellitus. J Trace Elem Exper Med 1995; 8: 183–190.

Ravina A, Slezak L, Mirsky N, Bryden NA, Anderson RA: Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999; 16: 164–167.

SCF: Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Trivalent Chromium, 2003.

Stearns DM et al.: Chromium (III) tris (picolinate) is mutagenic at the hypoxanthine (guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells. Mutat Res 2002; 513: 135–142.

Thomas VL, Gropper SS. Effect of chromium nicotinic acid supplementation on selected cardiovascular disease risk factors. Biol Trace Elem Res 1996; 55: 297–305.

Uusitupa MI, Mykkanen L, Siitonen O, Laakso M, Sarlund H, Kolehmainen P, Rasanen T, Kumpulainen J, Pyorala K: Chromium supplementation in impaired glucose tolerance of elderly: Effects on blood glucose, plasma insulin, C-peptide and lipid levels. Br J Nutr 1992; 68:209–216.

Vincent JB: Recent advances in the biochemistry of chromium(III). J Trace Elem Exp Med 2003;16:227–236.

Vincent JB. The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. Sports Med 2003; 33: 213–230.

Voelker R. Cancer risk in dietary supplement. JAMA 1999; 281: 1480.

Volpe SL, Huang HW, Larpadisorn K, Lesser II. Effect of chromium supplementation and exercise on body composition, resting metabolic rate and selected biochemical parameters in moderately obese women following an exercise program. J Am Coll Nutr. 2001;20:293-306.

Walker LS et al. Chromium picolinate effects on body composition and muscular performance in wrestlers. Med Sci Sports Exerc 1998; 30: 1730–1737.

Wallach S. Clinical and biochemical aspects of chromium deficiency. J Am Coll Nutr 1985; 4: 107–120.

Wasser WG, Feldman NS, D’Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. Ann Intern Med. 1997;126:410.

WHO, World Health Organisation. Trace elements in human nutrition and health (A Report of a re-evaluation of the role of trace elements in human health and nutrition). Geneva, 1996

Zha LY et al. Efficacy of chromium(III) supplementation on growth, body composition, serum parameters, and tissue chromium in rats Biol Trace Elem Res 2007; 119: 42–50.


Literaturliste zu Eisen

Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology. 2001;56:263-265.

Altamura S, Muckenthaler MU. Iron toxicity in diseases of aging: Alzheimer’s disease, Parkinson’s disease and atherosclerosis. J Alzheimers Dis. 2009;16:879-895.

Anderson GJ, Darshan D, Wilkins SJ, Frazer DM. Regulation of systemic iron homeostasis: how the body responds to changes in iron demand. Biometals. 2007;20:665-674.

Andrews NC: Disorders of iron metabolism. N Engl J Med 1999;341:1986–1995.

Ascherio A, Willett WC, Rimm EB, Giovannucci EL, Stampfer MJ. Dietary iron intake and risk of coronary disease among men. Circulation. 1994;89:969-974.

Baker WF, Jr.: Iron deficiency in pregnancy, obstetrics, and gynecology. Hematol Oncol Clin North Am 2000;14:1061–1077.

Balducci L: Anemia, cancer, and aging. Cancer Control 2003;10:478–486.

Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr. 2001;131:568S-579S.

Beguin Y: Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta 2003;329:9–22.

Benarroch EE. Brain iron homeostasis and neurodegenerative disease. Neurology. 2009;72:1436-1440.

Berglund S, Westrup B, Domellöf M. Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants. Pediatrics 2010; 126: 874–883.

Berkovitch M, Matsui D, Lamm SH, Rosa F, Koren G: Recent increases in numbers and risk of fatalities in young children ingesting iron preparations. Vet Hum Toxicol 1994;36:53–55.

Brigham D, Beard J: Iron and thermoregulation: A review. Crit Rev Food Sci Nutr 1996;36:747–763.

Brise H: Influence of meals on iron Resorption in oral iron therapy. Acta Med Scand 1962;171 (Suppl 376):39–45.

Brock JH: Benefits and dangers of iron during infection. Curr Opin Clin Nutr Metab Care 1999;2:507–510.

Brugnara C: Reticulocyte cellular indices: A new approach in the diagnosis of anemias and monitoring of erythropoietic function. Crit Rev Clin Lab Sci 2000;37:93–130.

Bulaj ZJ, Phillips JD, Ajioka RS, Franklin MR, Griffen LM, Guinee DJ, Edwards CQ, Kushner JP: Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda. Blood 2000; 95:1565–1571.

Cavill I: Intravenous iron as adjuvant therapy: A two-edged sword? Nephrol Dial Transplant 2003;18 Suppl 8:24–28.

Conrad ME, Umbreit JN: Pathways of iron Resorption. Blood Cells Mol 2002; Dis 29:336–355.

Danesh J, Appleby P. Coronary heart disease and iron status: meta-analyses of prospective studies. Circulation. 1999;99:852-854.

de Valk B, Marx JJ. Iron, atherosclerosis, and ischemic heart disease. Arch Intern Med. 1999;159(14):1542-1548.

Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP: Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 2000;54:1698-1700.

Earley CJ: Clinical practice. Restless legs syndrome. N Engl J Med 2003;348:2103–2109.

Fairweather-Tait SJ: Iron. J Nutr 2001;131:1383S– 1386S.

Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399-408.

Fleming DJ, Jacques PF, Tucker KL, et al. Iron status of the free-living, elderly Framingham Heart Study cohort: an iron-replete population with a high prevalence of elevated iron stores. Am J Clin Nutr. 2001;73:638-646.

Fleming MD. The regulation of hepcidin and its effects on systemic and cellular iron metabolism. Hematology Am Soc Hematol Educ Program. 2008:151-158.

Ganz T: Hepcidin in iron metabolism. Curr Opin Hematol 2004;11:251–254.

Gera T, Sachdev HP: Effect of iron supplementation on incidence of infectious illness in children: Systematic review. BMJ 2002;325:1142.

Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131:649S-666S.

Haas JD, Brownlie T: Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship. J Nutr 2001; 131:676S–688S.

Haile DJ: Regulation of genes of iron metabolism by the iron-response proteins. Am J Med Sci 1999; 318:230–240.

Hallberg L, Hulthen L: Prediction of dietary iron Resorption: an algorithm for calculating Resorption and bioavailability of dietary iron. Am J Clin Nutr 2000; 71:1147–1160.

Hernandez C, Lecube A, Carrera A, Simo R. Soluble transferrin receptors and ferritin in Type 2 diabetic patients. Diabet Med. 2005;22(1):97-101.

Hurrell RF: Bioavailability of iron. Eur J Clin Nutr 1997;51 Suppl 1:S4–S8.

Janssen MC, Swinkels DW. Hereditary haemochromatosis. Best Pract Res Clin Gastroenterol. 2009;23:171-183.

Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in US adults. Diabetes Care 2004;27:2422-2428.

Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 2004;291:711-717.

Kato I, Dnistrian AM, Schwartz M, et al. Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study. Int J Cancer. 1999;80:693-698.

Kaur D, Andersen JK: Ironing out Parkinson’s disease: Is therapeutic treatment with iron chelators a real possibility? Aging Cell 2002; 1:17–21.

Ke Y, Ming Qian Z: Iron misregulation in the brain: A primary cause of neurodegenerative disorders. Lancet Neurol 2003;2:246–253.

Kemp JD, Thorson JA, McAlmont TH, Horowitz M, Cowdery JS, Ballas ZK: Role of the transferrin receptor in lymphocyte growth: A rat IgG monoclonal antibody against the murine transferrin receptor produces highly selective inhibition of T and B cell activation protocols. J Immunol 1987;138:2422–2426.

Klipstein-Grobusch K, Grobbee DE, den Breeijen JH, Boeing H, Hofman A, Witteman JC. Dietary iron and risk of myocardial infarction in the Rotterdam Study. Am J Epidemiol. 1999;149(5):421-428.

Kruszewski M: Labile iron pool: The main determinant of cellular response to oxidative stress. Mutat Res 2003;531:81–92.

Lieu PT, Heiskala M, Peterson PA, Yang Y: The roles of iron in health and disease. Mol Aspects Med 2001;22:1–87.

Locatelli F, Aljama P, Barany P, Canaud B, Carrera F, Eckardt KU, Horl WH, Macdougal IC, Macleod A, Wiecek A, Cameron S: Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant 2004; 19 Suppl 2:1–47

Lovell MA, Robertson JD, Teesdale WJ, Campbell JL, Markesbery WR: Copper, iron and zinc in Alzheimer’s disease senile plaques. J Neurol Sci 1998;158:47–52.

Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(4 Suppl):560-571.

Ludwiczek S, Aigner E, Theurl I, Weiss G: Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 2003;101:4148–4154.

Lynch SR. Interaction of iron with other nutrients. Nutr Rev. 1997;55:102-110.

Mahomed K: Iron and folate supplementation in pregnancy. Cochrane Database Syst Rev 2000a CD001135

Mahomed K: Iron supplementation in pregnancy. Cochrane Database Syst Rev 2000b CD000117

McCann JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr 2007;85:931-945.

McCord JM: Iron, free radicals, and oxidative injury. Semin Hematol 1998;35:5–12.

Miret S, Simpson RJ, McKie AT: Physiology and molecular biology of dietary iron resorption. Annu Rev Nutr 2003;23:283–301.

Muckenthaler MU. Fine tuning of hepcidin expression by positive and negative regulators. Cell Metab 2008;8:1-3.

National Heart, Lung, and Blood Institute Working Group on Restless Legs Syndrome. Restless legs syndrome: detection and management in primary care. Am Fam Physician 2000;62:108-114.

Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-8785

Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-4601.

Nielsen P, Nachtigall D: Iron supplementation in athletes. Current recommendations. Sports Med 1998;26:207–216.

O’Keeffe ST, Noel J, Lavan JN: Restless legs syndrome in the elderly. Postgrad Med 1993; J 69:701–703.

Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr. 2001;131:616S-633S.

Pandolfo M: Friedreich ataxia. Semin Pediatr Neurol 2003;10:163–172.

Papanikolaou G, Pantopoulos K: Iron metabolism and toxicity. Toxicol Appl Pharmacol 2005;202:199–211.

Perry G, Sayre LM, Atwood CS, Castellani RJ, Cash AD, Rottkamp CA, Smith MA: The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. CNS Drugs 2002;16:339–352.

Picciano MF: Pregnancy and lactation: Physiological adjustments, nutritional requirements and the role of dietary supplements. J Nutr 2003; 133:1997S–2002S.

Pinero DJ, Hu J, Connor JR. Alterations in the interaction between iron regulatory proteins and their iron-responsive element in normal and Alzheimer’s diseased brains. Cell Mol Biol (Noisy-le-grand). 2000;46(4):761-776.

Rasmussen K. Is There a Causal Relationship between Iron Deficiency or Iron-Deficiency Anemia and Weight at Birth, Length of Gestation and Perinatal Mortality? J Nutr. 2001;131(2S-2):590S-601S.

Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr. 2005;8:117-132.

Sayre LM, Perry G, Atwood CS, Smith MA. The role of metals in neurodegenerative diseases. Cell Mol Biol. 2000;46:731-741.

Schols L, Meyer C, Schmid G, Wilhelms I, Przuntek H: Therapeutic strategies in Friedreich’s ataxia. J Neural Transm Suppl 2004;135– 145.

Shaskey DJ, Green GA: Sports haematology. Sports Med 2000;29:27–38.

Sherman PM, Macarthur C. Current controversies associated with Helicobacter pylori infection in the pediatric population. Front Biosci. 2001;6:E187-192.

Srigiridhar K, Nair KM (2000) Supplementation with alpha-tocopherol or a combination of alpha- tocopherol and ascorbic acid protects the gastrointestinal tract of iron-deficient rats against iron-induced oxidative damage during iron repletion. Br J Nutr 84:165–173.

Suharno D, West CE, Muhilal, Karyadi D, Hautvast JG. Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet. 1993;342(8883):1325-1328.

Sunder-Plassmann G, Patruta SI, Horl WH: Pathobiology of the role of iron in infection. Am J Kidney Dis 1999; 34:S25–S29.

Swaminathan S, Fonseca VA, Alam MG, Shah SV. The role of iron in diabetes and its complications. Diabetes Care. 2007;30:1926-1933.

Teraguchi S, Wakabayashi H, Kuwata H, Yamauchi K, Tamura Y: Protection against infections by oral lactoferrin: Evaluation in animal models. Biometals 2004;17:231–234.

Teucher B, Olivares M, Cori H: Enhancers of iron Resorption: Ascorbic acid and other organic acids. Int J Vitam Nutr Res 2004; 74:403– 419.

Thomas DG, Grant SL, Aubuchon-Endsley NL. The role of iron in neurocognitive development. Dev Neuropsychol 2009;34:196-222.

Thomas M, Jankovic J: Neurodegenerative disease and iron storage in the brain. Curr Opin Neurol 2004; 17:437–442.

Thompson KJ, Shoham S, Connor JR: Iron and neurodegenerative disorders. Brain Res Bull 2001; 55:155–164.

Todorich BM, Connor JR: Redox metals in Alzheimer’s disease. Ann NY Acad Sci 2004; 1012: 171–178.

Torti FM, Torti SV: Regulation of ferritin genes and protein. Blood 2002; 99:3505–3516.

Tuomainen TP, Nyyssonen K, Salonen R, Tervahauta A, Korpela H, Lakka T, Kaplan GA, Salonen JT: Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes Care 1997;20:426–428.

Wallander ML, Leibold EA, Eisenstein RS. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim Biophys Acta. 2006;1763:668-689.

Weaver CM, Rajaram S: Exercise and iron status. J Nutr 1992;122:782–787.

Wright RO, Tsaih SW, Schwartz J, Wright RJ, Hu H: Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic. J Pediatr 2003; 142:9–14.

Wright RO. The role of iron therapy in childhood plumbism. Curr Opin Pediatr. 1999;11:255-258.

Wurzelmann JI, Silver A, Schreinemachers DM, Sandler RS, Everson RB. Iron intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 1996;5:503-507

Yip R: Significance of an abnormally low or high hemoglobin concentration during pregnancy: Special consideration of iron nutrition. Am J Clin Nutr 2000;72:272S–279S.

Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR: Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 2004;5:863–873.


Literaturliste zu Jod

Als C, Fruhling J: Thyroid carcinoma: Administration of iodine-131 therapy early in the morning, please! Eur J Nucl Med 2000; 27:613–614.

Als C, Helbling A, Peter K, Haldimann M, Zimmerli B, Gerber H: Urinary iodine concentration follows a circadian rhythm: A study with 3023 spot urine samples in adults and children. J Clin Endocrinol Metab 2000; 85:1367– 1369.

Backer H, Hollowell J: Use of iodine for water disinfection: Iodine toxicity and maximum recommended dose. Environ Health Perspect 2000; 108:679–684.

Baker DH: Iodine toxicity and its amelioration. Exp Biol Med (Maywood) 2004; 229:473–478.

Becker DV, Braverman LE, Delange F, et al: Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid. 2006;16:949-951.

Bleichrodt N, Shrestha RM, West CE, Hautvast JG, van de Vijver FJ, Born MP: The benefits of adequate iodine intake. Nutr Rev. 1996;54:S72-78.

Caldwell KL, Miller GA, Wang RY, Jain RB, Jones RL: Iodine status of the U.S. population, National Health and Nutrition Examination Survey 2003-2004. Thyroid. 2008; 18: 1207-1214.

Cavalieri RR: Iodine metabolism and thyroid physiology: Current concepts. Thyroid 1997; 7:177–181.

Davidsson L. Are vegetarians an ‘at risk group’ for iodine deficiency? Br J Nutr. 1999;81:3-4.

de Benoist B, McLean E, Andersson M, Rogers L. Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull. 2008;29:195-202.

Delange F. Risks and benefits of iodine supplementation. Lancet. 1998;351:923-924.

DeLong GR, Leslie PW, Wang SH, et al. Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet. 1997;350:771-773.

Dietary Reference Intakes (2001) Iodine. In: A Report of the Panel of Micronutritients, Subcommittees on Upper Reference Levels of Nutritients and of the Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Ed. Food and Nutrition Board, Institute of Medicine, pp. 259–289.

Dunn JT. What’s happening to our iodine? J Clin Endocrinol Metab. 1998;83:3398-3400.

Eskin BA, Grotkowski CE, Connolly CP, Ghent WR. Different tissue responses for iodine and iodide in rat thyroid and mammary glands. Biol Trace Elem Res. 1995;49:9-19.

Feldt-Rasmussen U. Iodine and cancer. Thyroid. 2001;11:483-486.

Food and Nutrition Board, Institute of Medicine. Iodine. Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2001:258-289.

Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg. 1993;36:453-460.

Großklaus R, Jahreis G: Universelle Salzjodierung für Mensch und Tier. Ernährungsumschau 2004;51:139–143.

Hathcock JN: Trace element and supplement safety. In: Clinical Nutrition of the Essential Trace Elements and Minerals. Ed. Bogden JD, Klevay LM, pp. 99–111. Humana Press, Totowa, New Jersey, 2000

Hendler SS, Rorvik DM, eds. PDR for Nutritional Supplements. 2nd ed. Montvale: Thomson Reuters; 2008.

Hetzel BS, Clugston GA. Iodine. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams & Wilkins; 1999:253-264.

Hetzel BS. Iodine and neuropsychological development. J Nutr. 2000;130:493S-495S.

Higdon JA, Dunn JT: Iodine. In: Linus Pauling Institute Micronutrient Information Center, 2003

Hollowell JG, Staehling NW, Hannon WH, et al. Iodine nutrition in the United States. Trends and public health implications: iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-1974 and 1988-1994). J Clin Endocrinol Metab. 1998;83:3401-3408.

Houston R: Iodine. Physiology, dietary sources and requirements. In: Encyclopedia of Human Nutrition. Ed. Sadler MJ, Strain JJ, Caballero B, pp. 1138–1146. Academic Press, San Diego-London, 1999

Hurrell RF: Bioavailability of iodine. Eur J Clin Nutr 51 Suppl 1997; 1:S9–S12.

Kavishe FP: Iodine deficiency disorders. In: Encyclopedia of Human Nutrition. Ed. Sadler MJ, Strain JJ, Caballero B, pp. 1146–1153. Academic Press, San Diego-London, 1999

Kessler JH. The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia. Breast J. 2004;10:328-336.

Knudsen N, Bulow I, Laurberg P, Ovesen L, Perrild H, Jorgensen T. Association of tobacco smoking with goiter in a low-iodine-intake area. Arch Intern Med. 2002;162:439-443.

Köhrle J: Iod. In: Vitamine, Spurenelemente und Mineralstoffe. Prävention und Therapie mit Mikronährstoffen. Ed. Biesalski HK, Köhrle J, Schürmann K, pp. 172–182. Thieme, Stuttgart, 2000

Krajcovicova-Kudlackova M, Buckova K, Klimes I, Sebokova E: Iodine deficiency in vegetarians and vegans. Ann Nutr Metab 2003; 47:183–185.

Larsen PR, Davies TF, Hay ID. The thyroid gland. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Williams Textbook of Endocrinology. 9th ed. Philadelphia: W.B. Saunders Company; 1998:389-515.

Levander OA, Whanger PD. Deliberations and evaluations of the approaches, endpoints and paradigms for selenium and iodine dietary recommendations. J Nutr. 1996;126:2427S-2434S.

Lightowler HJ, Davies GJ: Iodine intake and iodine deficiency in vegans as assessed by the duplicate-portion technique and urinary iodine excretion. Br J Nutr 1998; 80:529–535.

Muranov K, Poliansky N, Winkler R, Rieger G, Schmut O, Horwath-Winter J: Protection by iodide of lens from selenite-induced cataract. Graefes Arch Clin Exp Ophthalmol 2004; 242:146–151.

National Academy Press, Washington DC Dunn JT: Trace element and mineral nutrition in endocrine disease. In: Clinical Nutrition of the Essential Trace Elements and Minerals. Ed. Bogden JD, Klevay LM, pp. 227– 238. Humana Press, Totowa, New Jersey, 2000

Nauman J, Wolff J. Iodide prophylaxis in Poland after the Chernobyl reactor accident: benefits and risks. Am J Med. 1993;94:524-532.

Nuclear Regulatory Commission. Consideration of potassium iodide in emergency plans. Nuclear Regulatory Commission. Final rule. Fed Regist. 2001;66:5427-5440.

Pennington JAT, Schoen SA, Salmon GD, Young B, Johnson RD, Marts RW. Composition of core foods of the U.S. food supply, 1982-1991. III. Copper, manganese, selenium, iodine. J Food Comp Anal. 1995;8:171-217.

Pennington JAT: Current dietary intakes of trace elements and minerals. In: Clinical Nutrition of the Essential Trace Elements and Minerals. Ed. Bogden JD, Klevay LM, pp. 49– 67. Humana Press, Totowa, New Jersey, 2000

Thomson CD, Woodruffe S, Colls A, Doyle TD. Urinary iodine and thyroid status of New Zealand residents. In: Roussel AM, Anderson RA, Favier A, eds. Trace Elements in Man and Animals. Vol 10. New York: Kluwer Academic Press; 2000:343-344.

Tiwari BD, Godbole MM, Chattopadhyay N, Mandal A, Mithal A. Learning disabilities and poor motivation to achieve due to prolonged iodine deficiency. Am J Clin Nutr. 1996;63:782-786.

United Nations Children’s Fund. The State of the World’s Children 2007, UNICEF. New York; 2006. p. 109.

Zanzonico PB, Becker DV. Effects of time of administration and dietary iodine levels on potassium iodide (KI) blockade of thyroid irradiation by 131I from radioactive fallout. Health Phys. 2000;78:660-667.

Zimmermann MB, Aeberli I, Torresani T, Burgi H. Increasing the iodine concentration in the Swiss iodized salt program markedly improved iodine status in pregnant women and children: a 5-y prospective national study. Am J Clin Nutr. 2005;82:388-392.

Zimmermann MB, Jooste PL, Pandav CS. Iodine-deficiency disorders. Lancet. 2008;372:1251-1262.


Literaturliste zu Kupfer

Abbott A. Neuroscience: The plaque plan. Nature. 2008;456:161–4.

Arredondo M, Nunez MT. Iron and copper metabolism. Mol Aspects Med. 2005;26:313–27.

Auclair S, Feillet-Coudray C, Coudray C, Schneider S, Muckenthaler MU, Mazur A. Mild copper deficiency alters gene expression of proteins involved in iron metabolism. Blood Cells Mol Dis. 2006;36:15–20.

Barnham KJ, Bush AI. Metals in Alzheimer’s and Parkinson’s diseases. Curr Opin Chem Biol. 2008;12:222–8.

Bonham M, O’Connor JM, Hannigan BM, Strain JJ: The immune system as a physiological indicator of marginal copper status? Br J Nutr 2002; 87:393–403.

Brewer GJ, Askari F, Dick RB, Sitterly J, Fink JK, Carlson M, et al. Treatment of Wilson’s disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine. Transl Res. 2009;154:70–7.

Brewer GJ: Copper in medicine. Curr Opin Chem Biol 2003; 7:207–212.

Brown DR. Brain proteins that mind metals: a neurodegenerative perspective. Dalton Trans.2009;4069–76.

Bügel S, Harper A, Rock E, et al: Effect of Copper Supplementation on Indices of Copper Status and Certain CVD Risk Markers in Young Healthy Women. Br J Nutr 2005; 94:231-6.

Castillo-Duran C, Fisberg M, Valenzuela A, et al: Controlled Trial of Copper Supplementation During the Recovery From Marasmus. Am J Clin Nutr 1983; 37:898-903.

Crichton RR, Pierre JL Old iron, young copper: from Mars to Venus. Biometals 2001;14:99–112.

Danks DM, Campbell PE, Walker-Smith J, Stevens BJ, Gillespie JM, Blomfield J. Menkes’s kinky-hair syndrome. Lancet. 1972;1:1100–2.

Danzeisen R, Araya M, Harrison B, Keen C, Solioz M, Thiele D, et al. How reliable and robust are current biomarkers for copper status? – reply by Danzeisen et al. Br J Nutr.2008;100:1343–4

Duffy EM, Meenagh GK, McMillan SA, et al: The Clinical Effect of Dietary Supplementation With Omega-3 Fish Oils and/or Copper in Systemic Lupus Erythematosus. J Rheumatol 2004; 31:1551-6.

Fairweather-Tait SJ: Bioavailability of copper. Eur J Clin Nutr 1997; 51 Suppl 1:S24–S26.

Ferenci P, Caca K, Loudianos G, Mieli-Vergani G, Tanner S, Sternlieb I, et al. Diagnosis and phenotypic classification of Wilson disease. Liver. 2003;23:139–42.

Ferretti G, Bacchetti T, Menanno F, et al: Effect of Genistein Against Copper-Induced Lipid Peroxidation of Human High Density Lipoproteins (HDL). Atherosclerosis 2004; 172:55-61.

Fitzgerald DJ: Safety guidelines for copper in water. Am J Clin Nutr 1998; 67:1098S–1102S.

Gibson RS: Assessment of trace element status in humans. Prog Food Nutr Sci 1989; 13:67– 111.

Gyorffy EJ and Chan H: Copper Deficiency and Microcytic Anemia Resulting From Prolonged Ingestion of Over-the-Counter Zinc. Am J Gastroenterol 1992; 87:1054-5.

Harvey LJ, Ashton K, Hooper L, Casgrain A, Fairweather-Tait SJ. Methods of assessment of copper status in humans: a systematic review. Am J Clin Nutr. 2009;89:2009S–24S.

Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annu Rev Nutr.2002;22:439–58.

Heseker H: Kupfer. Ernährungsumschau 1998; 45:215–217.

Huff JD, Keung YK, Thakuri M, Beaty MW, Hurd DD, Owen J, et al. Copper deficiency causes reversible myelodysplasia. Am J Hematol. 2007;82:625–30.

Huffman DL, O’Halloran TV. Function, structure, and mechanism of intracellular copper trafficking proteins. Annu Rev Biochem. 2001;70:677–701.

Hunt JR, Vanderpool RA: Apparent copper resorption from a vegetarian diet. Am J Clin Nutr 2001; 74:803–807.

Jiang Y, Reynolds C, Xiao C, Feng W, Zhou Z, Rodriguez W et al. Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice. J Exp Med. 2007;204:657–66.

Jones AA, DiSilvestro RA, Coleman M, et al: Copper Supplementation of Adult Men: Effects on Blood Copper Enzyme Activities and Indicators of Cardiovascular Disease Risk. Metabolism 1997; 46:1380-3.

Kaler SG, Holmes CS, Goldstein DS, Tang J, Godwin SC, Donsante A, et al. Neonatal diagnosis and treatment of Menkes disease. N Engl J Med. 2008;358:605–14.

Kaplan JH, Lutsenko S. Copper transport in mammalian cells: Special care for a metal with special needs. J Biol Chem. 2009;284:25461–5.

Kehoe CA, Turley E, Bonham MP, O’Connor JM, McKeown A, Faughnan MS, Coulter JS, Gilmore WS, Howard AN, Strain JJ: Response of putative indices of copper status to copper supplementation in human subjects. Br J Nutr 2000; 84:151–156.

Klevay LM: Lack of a recommended dietary allowance for copper may be hazardous to your health. J Am Coll Nutr 1998; 17:322–326.

Kucharzewski M, Braziewicz J, Majewska U, Gozdz S: Copper, zinc, and selenium in whole blood and thyroid tissue of people with various thyroid diseases. Biol Trace Elem Res 2003; 93:9–18.

Kumar N, Elliott MA, Hoyer JD, Harper CM, Jr., Ahlskog JE, Phyliky RL. “Myelodysplasia”, myeloneuropathy, and copper deficiency. Mayo Clin Proc. 2005;80:943–6.

Levenson CW: Mechanisms of copper conservation in organs. Am J Clin Nutr 1998; 67:978S–981S.

Linder MC, Wooten L, Cerveza P, Cotton S, Shulze R, Lomeli N: Copper transport. Am J Clin Nutr 1998; 67:965S–971S.

Lönnerdal B: Bioavailability of copper. Am J Clin Nutr 1996; 63:821S–829S.

Malhi H, Joseph B, Schilsky ML, Gupta S. Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease. Regen Med. 2008; 3: 165–73.

Mergle U, Schaefer M, Ferenc P, Stremmel W. Clinical presentation, diagnosis and long-term outcome of Wilson’s disease: a cohort study. Gut. 2007;56:115–20.

Merle U, Stremmel W, Encke J. Perspectives for gene therapy of Wilson disease. Curr Gene Ther. 2007;7:217–20.

Milne DB: Assessment of copper nutritional status. Clin Chem 1994; 40:1479–1484.

Moore RL, Feldman SM, Abbott LJ, et al: Evaluating the Anti-Plaque Capabilities of a Copper-Containing Prophylaxis Paste. J Periodontol 1989; 60:78-80.

Muller T, Muller W, Feichtinger H. Idiopathic copper toxicosis. Am J Clin Nutr1998;67:1082S–6S.

Natural Standard Research Collaboration, Chief Editors: Ulbricht C, Basch E, Natural Standard Herb and Supplement Reference – Evidence-Based Clinical Reviews, USA: Elsevier/Mosby, 2005

Olivares M, Pizarro F, Speisky H, Lönnerdal B, Uauy R: Copper in infant nutrition: Safety of World Health Organization provisional guideline value for copper content of drinking water. J Pediatr Gastroenterol Nutr 1998; 26:251–257.

Olivares M, Uauy R: Copper as an essential nutrient. Am J Clin Nutr 1996; 63:791S–796S.

Olivares M, Uauy R: Limits of metabolic tolerance to copper and biological basis for present recommendations and regulations. Am J Clin Nutr 1996; 63:846S–852S.

Patterson RA, Lamb DJ, and Leake DS: Mechanisms by Which Cysteine Can Inhibit or Promote the Oxidation of Low Density Lipoprotein by Copper. Atherosclerosis 2003; 169:87-94.

Saari JT: Copper deficiency and cardiovascular disease: Role of peroxidation, glycation, and nitration. Can J Physiol Pharmacol 2000; 78:848–855.

Santibanez M, Bolumar F, Garcia AM. Occupational risk factors in Alzheimer’s disease: a review assessing the quality of published epidemiological studies. Occup Environ Med. 2007;64:723–32.

Schürmann H, Classen HG, Dieter HH, König J, Mulhaupt G, Rückgauer M, Summer J, Bernhardt J, Biesalski HK: Hohenheim Consensus Workshop: Copper. Eur J Clin Nutr 2002; 56:469–483.

Schuschke DA: Dietary copper in the physiology of the microcirculation. J Nutr 1997; 127:2274–2281.

Silverstone BZ, Landau L, Berson D, et al: Zinc and Copper Metabolism in Patients With Senile Macular Degeneration. Ann Ophthalmol 1985; 17:419-22.

Singla PN, Chand P, Kumar A, et al: Serum, Zinc and Copper Levels in Children With Protein Energy Malnutrition. Indian J Pediatr 1996; 63:199-203.

Sorenson JR and Hangarter W: Treatment of Rheumatoid and Degenerative Diseases With Copper Complexes: A Review With Emphasis on Copper-Salicylate. Inflammation 1977; 2:217-38.

Strain JJ: A Reassessment of Diet and Osteoporosis – Possible Role for Copper. Med Hypotheses 1988; 27:333-8.

Tait SJ: Adaptive responses in men fed low- and high-copper diets. Br J Nutr 2003; 90:161–168.

Tapiero H, Townsend DM, Tew KD: Trace elements in human physiology and pathology. Copper. Biomed Pharmacother 2003; 57:386– 398.

Theophanides T, Anastassopoulou J: Copper and carcinogenesis. Crit Rev Oncol Hematol 2002; 42:57–64.

Turnlund JR. Human whole-body copper metabolism. Am J Clin Nutr. 1998;67:960S–4S.

Uauy R, Olivares M, Gonzalez M: Essentiality of copper in humans. Am J Clin Nutr 1998; 67:952S–959S.

Waggoner DJ, Bartnikas TB, Gitlin JD: The role of copper in neurodegenerative disease. Neurobiol Dis 1999; 6:221–230.

Walker WR, Keats DM: “An Investigation of the Therapeutic Value of the ‘Copper Bracelet’-Dermal Assimilation of Copper in Arthritic/Rheumatoid Conditions. Agents Actions 1976; 6:454-9.

Wapnir RA: Copper absorption and bioavailability. Am J Clin Nutr 1998; 67:1054S– 1060S.

WHO. Copper in Drinking-water. WHO 2004.

Wijmenga C, Klomp LW: Molecular regulation of copper excretion in the liver. Proc Nutr Soc 2004; 63:31–39.

Wilson SAK. Progressive lenticular degeneration: A familial nervous disease associated with cirrhosis of the liver. Brain. 1912; 34: 295–507. Abdullah AZ, Strafford SM, Brookes SJ, et al: The Effect of Copper on Demineralization of Dental Enamel. J Dent Res 2006; 85:1011-5.

Zatta P, Drago D, Bolognin S, Sensi SL. Alzheimer’s disease, metal ions and metal homeostatic therapy. Trends Pharmacol Sci. 2009;30:346–55.

Zhou Y, Bourcy K, Kang YJ. Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway. Cardiovasc Res. 2009;84:54–63.


Literaturliste zu Mangan

Aschner M, Erikson KM, Dorman DC: Manganese dosimetry: Species differences and implications for neurotoxicity. Crit Rev Toxicol 2005;35:1–32.

Baly DL, Schneiderman JS, and Garcia-Welsh AL: Effect of Manganese Deficiency on Insulin Binding, Glucose Transport and Metabolism in Rat Adipocytes. J Nutr 1990; 120:1075-9.

Barceloux DG: Manganese. J Toxicol Clin Toxicol 1999;37:293–307.

Christianson DW: Arginase: Structure, mechanism, and physiological role in male and female sexual arousal. Acc Chem Res 2005;38:191–201.

Chua AC, Morgan EH: Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol Trace Elem Res 1996;55:39–54.

Cox JD, Kim NN, Traish AM, Christianson DW: Arginase-boronic acid complex highlights a physiological role in erectile function. Nat Struct Biol 1999;6:1043–1047.

Crossgrove J, Zheng W: Manganese toxicity upon overexposure. NMR Biomed 2004;17:544–553.

Davidsson L, Almgren A, Juillerat MA, Hurrell RF: Manganese absorption in humans: The effect of phytic acid and ascorbic acid in soy formula. Am J Clin Nutr 1995;62:984–987.

Davidsson L, Cederblad A, Hagebo E, Lonnerdal B, Sandstrom B: Intrinsic and extrinsic labeling for studies of manganese absorption in humans. J Nutr 1988;118:1517–1521.

Davidsson L, Cederblad A, Lonnerdal B, Sandstrom B: The effect of individual dietary components on manganese absorption in humans. Am J Clin Nutr 1991;54:1065–1070.

Davidsson L, Lonnerdal B, Sandstrom B, Kunz C, Keen CL: Identification of transferrin as the major plasma carrier protein for manganese introduced orally or intravenously or after in vitro addition in the rat. J Nutr 1989;119:1461– 1464.

Davis CD, Greger JL: Longitudinal changes of manganese-dependent superoxid dismutase and other indixes of mangenase and iron status in woman, Am J Clin Nutr 1992; 55: 747–752.

Davis JM: Methylcyclopentadienyl manganese tricarbonyl: Health risk uncertainties and research directions. Environ Health Perspect 1998;106 Suppl 1:191–201.

DGE, Deutsche Gesellschaft für Ernährung: Ernährungsbericht 2004. Hrsg. Deutsche Gesellschaft für Ernährung e.V., Bonn, 2004.

Dobson AW, Erikson KM, Aschner M: Manganese neurotoxicity. Ann NY Acad Sci 2004;1012: 115–128.

Eid T, Thomas MJ, Spencer DD, Runden-Pran E, Lai JC, Malthankar GV, Kim JH, Danbolt NC, Ottersen OP, de Lanerolle NC: Loss of glutamine synthetase in the human epileptogenic hippocampus: Possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy. Lancet 2004;363:28–37.

El-Yazigi A: Urinary excretion of chromium, copper, and manganese in diabetes mellitus and associated disorders. Diabetes Re 1991; 18: 129–134.

Ensunsa JL, Symons JD, Lanoue L, Schrader HR, Keen CL: Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta. Exp Biol Med (Maywood) 2004;229:1143–1153.

Finley JW, Johnson PE, Johnson LK: Sex affects manganese absorption and retention by humans from a diet adequate in manganese. Am J Clin Nutr 1994;60:949–955.

Finley JW. Manganese absorption and retention by young woman is associated with serum ferritin concentrations, Am J Clin Nutr 1999; 70: 37–43.

Freeland-Graves JH, Behmardi F, Bales CW, Dougherty V, Lin PH, Crosby JB, Trickett PC: Metabolic balance of manganese in young men consuming diets containing five levels of dietary manganese. J Nutr 1988;118:764– 773.

Friedman BJ, Freeland-Graves JH, Bales CW, Behmardi F, Shorey-Kutschke RL, Willis RA, Crosby JB, Trickett PC, Houston SD: Manganese balance and clinical observations in young men fed a manganese-deficient diet. J Nutr 1987;117:133–143.

Gerber GB, Leonard A, Hantson P: Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol 2002;42:25–34.

Goering PL: The road to elucidating the mechanism of manganese-bilirubin-induced cholestasis. Toxicol Sci 2003;73:216–219.

Grant EC: Epilepsy and manganese. Lancet 2004; 363:572.

Greger JL, Davis CD, Suttie JW, Lyle BJ: Intake, serum concentrations, and urinary excretion of manganese by adult males. Am J Clin Nutr 1990;51:457–461.

Greger JL: Dietary standards for manganese: Overlap between nutritional and toxicological studies. J Nutr 1998;128:368S–371S.

Greger JL: Nutrition versus toxicology of manganese in humans: Evaluation of potential biomarkers. Neurotoxicology 1999;20:205–212.

HaMai D, Bondy SC: Oxidative basis of manganese neurotoxicity. Ann NY Acad Sci 2004;1012:129–141.

Hambidge KM, Sokol RJ, Fidanza SJ, Goodall MA: Plasma manganese concentrations in infants and children receiving parenteral nutrition. JPEN J Parenter Enteral Nutr 1989;13:168–171.

Heseker H. Mangan. Funktionen, Physiologie, Stoffwechsel, Empfehlungen und Versorgung in der Bundesrepublik Deutschland. Ernährungs-Umschau 2000; 47: 64–65.

Huang CC, Chu NS, Lu CS, Wang JD, Tsai JL, Tzeng JL, Wolters EC, Calne DB: Chronic manganese intoxication. Arch Neurol 1989; 46: 1104–1106.

Huang CC, Lu CS, Chu NS, Hochberg F, Lilienfeld D, Olanow W, Calne DB: Progression after chronic manganese exposure. Neurology 1993; 43:1479–1483.

Johnson PE, Lykken GI. Manganese and calcium absorption and balance in young woman fed diets with varying amounts of manganese and calcium, J Trace Elem Exp Med 1991; 4: 19–35

Keen CL, Ensunsa JL, Watson MH, Baly DL, Donovan SM, Monaco MH, Clegg MS: Nutritional aspects of manganese from experimental studies. Neurotoxicology 1999; 20:213–223.

Kelly DA: Liver complications of pediatric parenteral nutrition–epidemiology. Nutrition 1998;14:153–157.

Kocyigit A, Zeyrek D, Keles H, Koylu A: Relationship among manganese, arginase, and nitric oxide in childhood asthma. Biol Trace Elem Res 2004;102:11–18.

Kondakis XG, Makris N, Leotsinidis M, Prinou M, Papapetropoulos T: Possible health effects of high manganese concentration in drinking water. Arch Environ Health 1989;44:175– 178.

Layrargues GP, Rose C, Spahr L, Zayed J, Normandin L, Butterworth RF: Role of manganese in the pathogenesis of portal-systemic encephalopathy. Metab Brain Dis 1998;13:311–317.

Layrargues GP, Shapcott D, Spahr L, Butterworth RF: Accumulation of manganese and copper in pallidum of cirrhotic patients: Role in the pathogenesis of hepatic encephalopathy? Metab Brain Dis 1995;10:353–356.

Macmillan-Crow LA, Cruthirds DL: Invited review: Manganese superoxide dismutase in disease. Free Radic Res 2001;34:325–336.

Malecki EA and Greger JL: Manganese Protects Against Heart Mitochondrial Lipid Peroxidation in Rats Fed High Levels of Polyunsaturated Fatty Acids. J Nutr 1996; 126:27-33.

Nath N. Superoxide dismutase in diabetes polymorphonuclear leucocytes. Diabetes 1984; 33: 586–589.

O’Dell BL: Mineral interactions relevant to nutrient requirements. J Nutr 1989;119:1832–1838.

Odabasi E et al. Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis? Ann Acad Med Singapore 2008; 37: 564–567.

Ohno H, Kayashima S, Nagata N, Yamashita H, Ookawara T, Taniguchi N: Changes in immunoreactive manganese-superoxide dismutase concentration in human serum after 93 h strenuous physical exercise. Clin Chim Acta 1993;215:213–219.

Olanow CW: Manganese-induced parkinsonism and Parkinson’s disease. Ann NY Acad Sci 2004;1012:209–223.

Pal PK, Samii A, Calne DB: Manganese neurotoxicity: A review of clinical features, imaging and pathology. Neurotoxicology 1999; 20: 227–238.

Papavasilious PS, Kutt H, Miller ST, et al: Seizure Disorders and Trace Metals: Manganese Tissue Levels in Treated Epileptics. Neurology 1979; 29:1466-73.

Paynter DI: Changes in activity of the manganese superoxide dismutase enzyme in tissues of the rat with changes in dietary manganese. J Nutr 1980; 110:437–447.

Penland JG, Johnson PE: Dietary calcium and manganese effects on menstrual cycle symptoms. Am J Obstet Gynecol 1993;168:1417– 1423.

Saltman PD and Strause LG: The Role of Trace Minerals in Osteoporosis. J Am Coll Nutr 1993 ;12:384-9.

Sandstrom B, Davidsson L, Eriksson R, Alpsten M: Effect of long-term trace element supplementation on blood trace element levels and absorption of (75Se), (54Mn) and (65Zn). J Trace Elem Electrolytes Health Dis 1990;4:65–72.

Sandstrom B: Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr 2001;85 Suppl 2:S181–S185.

SCF: Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of manganese. Guidelines of the Scientific Committee on Food for the development of tolerable upper intake levels for vitamins and minerals. SCF/CS/NUT/UPPLEV/11 Final (2000).

Spahr L, Burkhard PR, Grotzsch H, Hadengue A: Clinical significance of basal ganglia alterations at brain MRI and 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy. Metab Brain Dis 2002;17:399–413.

Spahr L, Butterworth RF, Fontaine S, Bui L, Therrien G, Milette PC, Lebrun LH, Zayed J, Leblanc A, Pomier-Layrargues G: Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Hepatology 1996;24:1116–1120.

Strause L, Saltman P, Smith KT, Bracker M, Andon MB: Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994;124:1060–1064.

Vieregge P, Heinzow B, Korf G, Teichert HM, Schleifenbaum P, Mosinger HU: Long term exposure to manganese in rural well water has no neurological effects. Can J Neurol Sci 1995;22:286–289.

Walter RM. Acute oral manganese does not consistently affect glucose tolerance in nondiabetic and type II diabetic humans. J Trace Elem Exp Med 1991;4:73–79.

Walter RM. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care 1991; 14: 1050–1056.


Literaturliste zu Molybdän

Abumrad NN, Schneider AJ, Steel D, Rogers LS. Amino acid intolerance during prolonged parenteral nutrition reversed by molybdate therapy. Amer J Clin Nutr 1984;34: 2551-2559.

Blot WJ, Li JY, Taylor P.R. et al: Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993; 85: 1483-1492.

Bompart G, Pecher C, Prevet D, Girolami JP. Mild renal failure induced by subchronic exposure to molybdenum, urinary kallikrein excretion as a marker of distal tubular effect. Toxicol Lett 1990;52: 293-300.

Deosthale and Gopalan C. The effect of molybdenum levels in sorghum on uric acid and copper excretion in man. Brit J Nutr 1974;31: 351-355.

Federmann M, Morell B, Graetz G, Wyss M, Elsner P, von Thiessen R, Wuthrich B, Grob D. Hypersensitivity to molybdenum as a possible trigger of ANA-negative systemic lupus erythematosus. Ann Rheum Dis 1994; 53: 403-5

Fungwe TV, Buddingh F, Demick DS, Lox CD, Yang MT, Yang SP. The role of dietary molybdenum on oestrous activity, fertility, reproduction and molybdenum and copper enzyme activities of female rats. Nutr Res 1990;10: 515-524.

Hendler SS, Rorvik DR: PDR for Nutritional Supplements. Montvale: Medical Economics Company, Inc 2001;308-311.

Holzinger S, Anke M, Röhrig B, Gonzalez D. Molybdenum intake of adults in Germany and Mexico. Analyst. 1998;123:447-50.

IOM Institute of Medicine, Food and Nutrition Board: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Borone, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. National Academy Press; Washington, USA, 2002

Luo XM, Wei HJ, Yang SP. Inhibitory effects of molybdenum on oesophageal and forestomach carcinogenesis in rats. JNCI 1983;71: 75-80.

Niestroj I. Praxis der Orthomolekularen Medizin. Hippokrates Verlag GmbH, Stuttgart 2000

Nishioka H. Mutagenic activities of metal compounds in bacteria. Mutation Res 1975; 31: 185-189.

Rehner G, Daniel H. Biochemie der Ernährung. Spektrum Akademischer Verlag, Heidelberg, Berlin, 2002

Reiss J. Genetics of molybdenum cofactor deficiency. Hum Genet 2000; 106: 157-63.

Schroeder HA, Mitchener M. Toxic effects of trace elements on the reproduction of mice and rats. Arch Environm Health 1971;23:102-106.

Schwarz G, Mendel RR, Ribbe MW. Molybdenum cofactors, enzymes and pathways. Nature 2009; 460: 839–847.

Stiefel ES, Coucouvanis D, Newton WE. Molybdenum enzymes, cofactors and model systems. American Chemical Society, Washington DC, 1993.

Suttle NF. The role of thiomolybdates in the nutritional interactions of copper, molybdenum and sulfur: fact or fantasy? Annals NY Acad Sc 1980;355: 195-207.

Turnlund JR, Keyes WR. Plasma molybdenum reflects dietary molybdenum intake. J Nutr Biochem 2004;15:90–95.

Turnlund JR, Keyes WR, Peiffer GL, Chiang G. Molybdenum absorption, excretion, and retention studied with stable isotopes in young men during depletion and repletion. Am J Clin Nutr 1995; 61:1102–1109.

Turnlund JR, Weaver CM, Kim SK, Keyes WR, Gizaw Y, Thompson KH, Peiffer GL. Molybdenum absorption and utilization in humans from soy and kale intrinsically labelled with stable isotopes of molybdenum. Am J Clin Nutr 1999;69:1217–1223.

Vyskocil A and Viau C. Assessment of molybdenum toxicity in humans. J Appl Toxicol 1999;19: 185-192.

Walravens PA, Moure-Eraso R, Solomons CC, Chappel WR and Bentley G. Biochemical abnormalities in workers exposed to molybdenum dust. Ach Environ health 1979; 34: 302-308.

Wei HJ, Luo XM and Yang SP. Effects of molybdenum and tungsten on mammary carcinogenesis in SD rats. JNCI 1985;74: 469-473.

Wuebbens MM, Liu MT, Rajagopalan K, Schindelin H. Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC. Structure Fold Des 2000; 8: 709-718.


Literaturliste zu Selen

Akbaraly NT, Arnaud J, Hininger-Favier I, Gourlet V, Roussel AM, Berr C. Selenium and mortality in the elderly: results from the EVA study. Clin Chem 2005; 51: 2117–2123.

Arthur JR, McKenzie RC, Beckett GJ: Selenium in the immune system. J Nutr 2003;133:1457S–1459S.

Arthur JR. The glutathione peroxidases. Cell Mol Life Sci 2000; 57 (13–14): 1825–1835.

Avenell A, Noble DW, Barr J, Engelhardt T: Selenium supplementation for critically ill adults. Cochrane Database Syst Rev CD003703, 2004.

Azrak RG, Cao S, Pendyala L, et al: Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent. Biochem Pharmacol. 2007;73:1280-1287.

Baum MK, Miguez-Burbano MJ, Campa A, Shor-Posner G: Selenium and interleukins in persons infected with human immunodeficiency virus type 1. J Infect Dis 2000;182 Suppl 1:69-73.

Baum MK: Role of micronutrients in HIV-infected intravenous drug users. J Acquir Immune Defic Syndr 25 Suppl 2000; 1:49–S52.

Beck MA, Nelson HK, Shi Q, Van Dael P, Schiffrin EJ, Blum S, Barclay D, Levander OA: Selenium deficiency increases the pathology of an influenza virus infection. FASEB J 2001; 15: 1481–1483.

Beck MA: Increased virulence of coxsackievirus B3 in mice due to vitamin E or selenium deficiency. J Nutr 1997; 127:966–970 .

Beck MA: Selenium and viral infections. In: Hatfield DL, Berry MJ, Gladyshev VN, eds. Selenium: Its Molecular Biology and Role in Human Health. 2nd ed. New York: Springer; 2006:287-298.

Beckett GJ, Arthur JR: Selenium and endocrine systems. J Endocrinol 2005; 184:455–465.

Behne D, Kyriakopoulus A.Mammalian selenium containing proteins. Annu Rev Nutr 2001; 21: 453–473.

Benton D: Selenium intake, mood and other aspects of psychological functioning. Nutr Neurosci 2002; 5:363–374.

Blot WJ, Li JY, Taylor PR, Guo W, Dawsey SM, Li B: The Linxian trials: Mortality rates by vitamin-mineral intervention group. Am J Clin Nutr 1995;62:1424S–1426S.

Brigelius-Flohe R, Muller C, Menard J, Florian S, Schmehl K, Wingler K: Functions of GIGPx: Lessons from selenium-dependent expression and intracellular localization. Biofactors 2001;14:101–106.

Brinkman M, Reulen RC, Kellen E, Buntinx F, Zeegers MP: Are men with low selenium levels at increased risk of prostate cancer? Eur J Cancer. 2006;42:2463-2471.

Brown KM, Arthur JR: Selenium, selenoproteins and human health: A review. Public Health Nutr 2001;4:593–599.

Burbano X, Miguez-Burbano MJ, McCollister K, Zhang G, Rodriguez A, Ruiz P, Lecusay R, Shor-Posner G: Impact of a selenium chemoprevention clinical trial on hospital admissions of HIV-infected participants. HIV Clin Trials 2002;3:483–491.

Canter PH, Wider B, Ernst E. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials. Rheumatology (Oxford) 2007; 46: 1223–1233.

Clark LC, Combs GF, Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL, Jr, Park HK, Sanders BB, Jr, Smith CL, Taylor JR: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 1996;276:1957–1963.

Clark LC, Marshall JR: Randomized, controlled chemoprevention trials in populations at very high risk for prostate cancer: Elevated prostate-specific antigen and high-grade prostatic intraepithelial neoplasia. Urology. 2001;57:185-187.

Combs GF Jr, Clark LC, Turnbull BW. An analysis of cancer prevention by selenium. Biofactors 2001; 14: 153–159.

Combs GF Jr. Current evidence and research needs to support a health claim for selenium and cancer prevention. J Nutr 2005; 135: 343–347.

Daniels LA: Selenium metabolism and bioavailability. Biol Trace Elem Res 1996; 54: 185–199.

Demelash A, Karlsson JO, Nilsson M, Bjorkman U: Selenium has a protective role in caspase-3-dependent apoptosis induced by H2O2 in primary cultured pig thyrocytes. Eur J Endocrinol 2004 ;150:841–849.

Diwadkar-Navsariwala V, Diamond AM: The link between selenium and chemoprevention: A case for selenoproteins. J Nutr 2004; 134:2899–2902.

Duffield-Lillico AJ, Dalkin BL, Reid ME, Turnbull BW, Slate EH, Jacobs ET, Marshall JR, Clark LC. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. British Journal of Urology 2003; 91: 608–612.

Duffield-Lillico AJ, Reid ME, Turnbull BW, Combs GF Jr, Slate EH, Fischbach LA, Marshall JR, Clark LC. Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev 2002; 11: 630–639.

Duffield-Lillico AJ, Slate EH, Reid ME, et al: Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst. 2003;95:1477-1481.

Duntas LH, Mantzou E, Koutras DA: Effects of a six-month treatment with selenomethionine in patients with autoimmune thyroiditis. Eur J Endocrinol 2003;148:389–393.

Dworkin BM. Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). Chem Biol Interact 1994; 91: 181–186.

Fleming J, Ghose A, Harrison PR: Molecular mechanisms of cancer prevention by selenium compounds. Nutr Cancer 2001;40:42–49.

Food and Nutrition Board, Institute of Medicine. Selenium. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington D.C.: National Academy Press; 2000:284-324.

Gartner R, Gasnier BC : Selenium in the treatment of autoimmune thyroiditis. Biofactors 2003;19:165–170.

Ghadirian P, Maisonneuve P, Perret C, et al: A case-control study of toenail selenium and cancer of the breast, colon, and prostate. Cancer Detect Prev. 2000;24:305-313.

Hawkes WC, Keim NL: Dietary selenium intake modulates thyroid hormone and energy metabolism in men. J Nutr 2003; 133:3443–3448.

Heyland DK, Dhaliwal R, Suchner U, Berger MM: Antioxidant nutrients: A systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med 2005;31:327– 337.

Hu G, Cassano PA: Antioxidant nutrients and pulmonary function: the Third National Health and Nutrition Examination Survey (NHANES III). Am J Epidemiol 2000; 151: 975–981.

Hurwitz BE, Klaus JR, Llabre MM, et al: Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: a randomized controlled trial. Arch Intern Med. 2007;167:148-154.

Kardinaal AF, Kok FJ, Kohlmeier L, et al: Association between toenail selenium and risk of acute myocardial infarction in European men. The EURAMIC Study. European Antioxidant Myocardial Infarction and Breast Cancer. Am J Epidemiol. 1997;145:373-379.

Khalili H, Soudbakhsh A, Hajiabdolbaghi M, Dashti-Khavidaki S, Poorzare A, Saeedi AA, Sharififar R.Nutritional status and serum zinc and selenium levels in Iranian HIV infected individuals. BMC Infect Dis 2008; 8: 165.

Knekt P, Heliövaara M, Aho K, Alfthan G, Marniemi J, Aromaa A. Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology 2000; 11: 402–405.

Larsson Ch, Johansson GK. Dietary intake and nutritional status of young vegans and omnivores in Sweden. Am J Clin Nutr 2002; 76: 100–106.

Lawson KA, Wright ME, Subar A, et al: Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst. 2007;99:754-764.

Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, Parsons JK, Bearden JD 3rd, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, Lieber MM, Kristal AR, Darke AK, Arnold KB, Ganz PA, Santella RM, Albanes D, Taylor PR, Probstfield JL, Jagpal TJ, Crowley JJ, Meyskens FL Jr, Baker LH, Coltman CA Jr.Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009; 301: 39–51.

Pedersen M, Stripp C, Klarlund M, Olsen SF, Tjønneland AM, Frisch M. Diet and risk of rheumatoid arthritis in a prospective cohort. J Rheumatol 2005; 32: 1249–1252.

Peretz A, Siderova V, Nève J. Selenium supplementation in rheumatoid arthritis investigated in a double blind, placebo- controlled trial. Scand J of Rheumatol 2001; 30: 208–212.

Persson-Moschos ME, Stavenow L, Akesson B, Lindgärde F. Selenoprotein P in plasma in relation to cancer morbidity in middle-aged Swedish men. Nutr Cancer 2000; 36: 19–26.

Rayman MP, Bode P, Redman CW : Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom. Am J Obstet Gynecol 2003; 189:1343–1349.

Rayman MP. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 2005; 64: 527–542.

Rayman MP: The importance of selenium to human health. Lancet. 2000;356:233-241.

Rayman MP: The use of high-selenium yeast to raise selenium status: How does it measure up?. Br J Nutr 2004; 92:557–573.

Reeves MA, Hoffmann PR. The human selenoproteome: recent insights into functions and regulation. Cell Mol Life Sci 2009; 66: 2457–2478

Reid ME, Duffield-Lillico AJ, Garland L, Turnbull BW, Clark LC, Marshall JR: Selenium supplementation and lung cancer incidence: an update of the nutritional prevention of cancer trial. Cancer Epidemiol Biomarkers Prev. 2002;11:1285-1291.

Schrauzer GN. Selenomethionine: A review of its nutritional significance, metabolism and toxicity. J Nutr 2000; 130: 1653–1656.

Schrauzer GN: Nutritional selenium supplements: Product types, quality, and safety. J Am Coll Nutr 2001;20:1–4.

Schrauzer GN: The nutritional significance, metabolism and toxicology of selenomethionine. Adv Food Nutr Res 2003; 47:73–112.

Scott R, MacPherson A, Yates RW, Hussain B, Dixon J: The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998; 82:76–80.

Shaheen SO, Sterne JA, Thompson RL, Songhurst CE, Margetts BM, Burney PG: Dietary antioxidants and asthma in adults: Population-based case-control study. Am J Respir Crit Care Med 2001; 164:1823–1828.

Sieja K, Talerczyk M: Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecol Oncol 2004; 93:320–327.

Sievers E, Arpe T, Schleyerbach U, Garbe-Schonberg D, Schaub J: Plasma selenium in preterm and term infants during the first 12 months of life. J Trace Elem Med Biol 2001; 14:218– 222.

Squires JE, Berry MJ. Eukaryotic selenoprotein synthesis: mechanistic insight incorporating new factors and new functions for old factors. IUBMB Life 2008; 60: 232–235.

Stranges S, Marshall JR, Natarajan R, et al: Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes: A Randomized Trial. Ann Intern Med. 2007;147:217-223.

Suzuki KT, Ogra Y. Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se. Food Addit Contam 2002; 19: 974–983.

Tan J, Zhu W, Wang W, Li R, Hou S, Wang D, Yang L: Selenium in soil and endemic diseases in China. Sci Total Environ 2002; 284:227–235.

Thomson CD. Assessment of requirements for selenium and adequacy of selenium status: a review. Eur J Clin Nutr 2004; 58: 391–402.

Virtamo J, Valkeila E, Alfthan G, Punsar S, Huttunen JK, Karvonen MJ: Serum selenium and the risk of coronary heart disease and stroke. Am J Epidemiol. 1985;122:276-282.

Vrca VB, Skreb F, Cepelak I, Romic Z, Mayer L: Supplementation with antioxidants in the treatment of Graves’ disease; the effect on glutathione peroxidase activity and concentration of selenium. Clin Chim Acta 2004; 341:55–63.

Whanger PD. Selenium and its relationship to cancer: an update. Br J Nutr 2004; 91: 11–28.

Yoshizawa K, Ascherio A, Morris JS, Stampfer MJ, Giovannucci E, Baskett CK, Willett WC, Rimm EB. Prospective study of selenium levels in toenails and risk of coronary heart disease in men. Am J Epidemiol 2003; 158 (9): 852–860.

Zamamiri-Davis F, Lu Y, Thompson JT, Prabhu KS, Reddy PV, Sordillo LM, Reddy CC. Nuclear factor-kappaB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency. Free Radic Biol Med 2002; 32: 890–897.

Zhuo H, Smith AH, Steinmaus C: Selenium and lung cancer: a quantitative analysis of heterogeneity in the current epidemiological literature. Cancer Epidemiol Biomarkers Prev. 2004;13:771-778.


Literaturliste zu Zink

Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001; 119: 1417–1436.

Al-Gurairi, FT, Al-Waiz, M, Sharquie, KE: Oral Zinc Sulphate in the Treatment of Recalcitrant Viral Warts: Randomized Placebo-Controlled Clinical Trial. Br J Dermatol 2002; 146:423.

Angus, RM, Sambrook, PN, Popcock, NA, et al: Dietary Intake and Bone Mineral Density. Bone Miner 1988; 4:265.

Arcasoy, A, Cavdar, A, Cin, S, et al: Effects of Zinc Supplementation on Linear Growth in Beta-Thalassemia (A New Approach). Am J Hematol 1987; 24:127.

Arendt T: Alzheimer’s disease as a disorder of dynamic brain self-organization. Prog Brain Res 2005; 147:355–378.

Arnold J, Sarks S: Age-related macular degeneration. Clin Evid 2004; 819–834.

Atkinson SA, Whelan D, Whyte RK, Lonnerdal B: Abnormal zinc content in human milk. Risk for development of nutritional zinc deficiency in infants. Am J Dis Child 1989; 143:608–611.

Baer MT, King JC: Tissue zinc levels and zinc excretion during experimental zinc depletion in young men. Am J Clin Nutr 1984; 39:556–570.

Ball MJ, Ackland ML: Zinc intake and status in Australian male vegetarians. Br J Nutr 2000; 83: 27–33.

Bandyopadhyay B, Bandyopadhyay SK: Protective effect of zinc gluconate on chemically induced gastric ulcer. Indian J Med Res 1997; 106:27–32.

Baum MK, Shor-Posner G, Campa A: Zinc status in human immunodeficiency virus infection. J Nutr 2000; 130 : 1421S–3S.

Beals KA, Manore MM: Nutritional status of female athletes with subclinical eating disorders. J Am Diet Assoc 1998; 98: 419–425.

Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, Khatun F, Martorell R, Ninh NX, Penny ME, Rosado JL, Roy SK, Ruel M, Sazawal S, Shankar A: Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: Pooled analysis of randomized controlled trials. Am J Clin Nutr 2000; 72:1516–1522.

Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, Khatun F, Martorell R, Ninh NX, Penny ME, Rosado JL, Roy SK, Ruel M, Sazawal S, Shankar A : Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: Pooled analysis of randomized controlled trials. Zinc Investigators’ Collaborative Group. J Pediatr 1999; 135:689–697.

Black RE : Zinc deficiency, infectious disease and mortality in the developing world. Journal of Nutrition 2003; 133: 1485S– 1489S.

Black RE: Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. Am J Clin Nutr 1998; 68 : 476S–479S.

Bobat, R, Coovadia, H, Stephen, C, et al: Safety and Efficacy of Zinc Supplementation for Children With HIV-1 Infection in South Africa: A Randomised Double-Blind Placebo-Controlled Trial. Lancet 2005; 366:1862.

Brewer, GJ, Dick, RD, Johnson, VD, et al: Treatment of Wilson’s Disease With Zinc. XVI: Treatment During the Pediatric Years. J Lab Clin Med 2001; 137:191.

Carcamo, C, Hooton, T, Weiss, NS, et al: Randomized Controlled Trial of Zinc Supplementation for Persistent Diarrhea in Adults With HIV-1 Infection. J Acquir Immune Defic Syndr 2006; 43:197.

Caruso TJ, Prober CG, Gwaltney JM Jr: Treatment of naturally acquired common colds with zinc: a structured review. Clin Infect Dis 2007; 45 : 569–574.

Coles CL, Bose A, Moses PD, Mathew L, Agarwal I, Mammen T, Santosham M. Infectious Etiology Modifies the Treatment Effect of Zinc in Severe Pneumonia. Am J Clin Nutr 2007; 86:397.

Chang, AB, Torzillo, PJ, Boyce, NC, et al: Zinc and Vitamin A Supplementation in Indigenous Australian Children Hospitalised With Lower Respiratory Tract Infection: A Randomised Controlled Trial. Med J Aust 2006; 184:107.

Cho E, Stampfer MJ, Seddon JM et al: Prospective study of zinc intake and the risk of age-related macular degeneration. Ann Epidemiol 2001; 11 : 328–336.

Chong EW, Wong TY, Kreis AJ et al: Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 2007; 335 : 755.

Dardenne M: Zinc and immune function. Eur J Clin Nutr 2002; 56 : S20–S23.

Davis CD, Milne DB, Nielsen FH: Changes in dietary zinc and copper affect zinc-status indicators of postmenopausal women, notably, extracellular superoxide dismutase and amyloid precursor proteins. Am J Clin Nutr 2000; 71: 781–788.

Evans J: Antioxidant supplements to prevent or slow down the progression of AMD: a systematic review and meta-analysis. Eye 2008; 22 : 751–760.

Evans JR, Henshaw K: Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database Syst Rev 2008; (1): CD000253.

Evans JR: Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev 2006; CD000254.

Fischer Walker, CL, Bhutta, ZA, Bhandari, N, et al: Zinc Supplementation for the Treatment of Diarrhea in Infants in Pakistan, India and Ethiopia. J Pediatr Gastroenterol Nutr 2006; 43:357.

Fortes C, Forastiere F, Agabati N et al: The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc 1998; 46: 19–26.

Fraker PJ, King LE, Laakko T et al: The dynamic link between the integrity of the immune system and zinc status. J Nutr 2000; 130: 1399S–1406S.

Godfrey HR, Godfrey NJ, Godfrey JC, et al: A Randomized Clinical Trial on the Treatment of Oral Herpes With Topical Zinc Oxide/Glycine. Altern Ther Health Med 2001; 7:49.

Gregorio GV, Dans LF, Cordero CP, et al: Zinc Supplementation Reduced Cost and Duration of Acute Diarrhea in Children. J Clin Epidemiol 2007; 60:560.

Gupta DN, Rajendran K, Mondal SK, et al: Operational Feasibility of Implementing Community-Based Zinc Supplementation: Impact on Childhood Diarrheal Morbidity. Pediatr Infect Dis J 2007; 26:306.

Gupta VL, Chaubey BS: RBC Survival, Zinc Deficiency, and Efficacy of Zinc Therapy in Sickle Cell Disease. Birth Defects Orig Artic Ser 1987; 23:477.

Hahn A, Ströhle A, Wolters M: Ernährung – Physiologische Grundlagen, Prävention, Therapie, 2. Aufl. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH; 2006.

Halyard MY, Jatoi A, Sloan JA, et al: Does Zinc Sulfate Prevent Therapy-Induced Taste Alterations in Head and Neck Cancer Patients? Results of Phase III Double-Blind, Placebo-Controlled Trial From the North Central Cancer Treatment Group (N01C4). Int J Radiat Oncol Biol Phys 2007; 67:1318.

Hulisz D: Efficacy of zinc against common cold viruses: an overview. J Am Pharm Assoc 2003: 44(5), 594–603 (2004).

Jackson JL, Lesho E, Peterson C: Zinc and the common cold: a meta-analysis revisited. J Nutr 2000; 130 : 1512S–1515S.

Jager RD, Mieler WF, Miller JW: Age-related macular degeneration. N Engl J Med 2008; 358 : 2606– 2617.

Larson CP, Hoque AB, Larson CP, et al: Initiation of Zinc Treatment for Acute Childhood Diarrhoea and Risk for Vomiting or Regurgitation: A Randomized, Double-Blind, Placebo-Controlled Trial. J Health Popul Nutr 2005; 23:311.

Lin LC, Que J, Lin LK, et al: Zinc Supplementation to Improve Mucositis and Dermatitis in Patients After Radiotherapy for Head-and-Neck Cancers: A Double-Blind, Randomized Study. Int J Radiat Oncol Biol Phys 2006; 65:745.

Long KZ, Montoya Y, Hertzmark E, et al: A Double-Blind, Randomized, Clinical Trial of the Effect of Vitamin A and Zinc Supplementation on Diarrheal Disease and Respiratory Tract Infections in Children in Mexico City, Mexico. Am J Clin Nutr 2006; 83:693.

Long KZ, Rosado JL, Montoya Y, et al: Effect of Vitamin A and Zinc Supplementation on Gastrointestinal Parasitic Infections Among Mexican Children. Pediatrics 2007; 120:e846.

Lönnerdal B: Dietary factors influencing zinc absorption. J Nutr 2000; 130: 1378S–1383S.

Macknin ML, Piedmonte M, Calendine C et al: Zinc gluconate lozenges for treating the common cold in children: a randomized controlled trial. JAMA 1998; 279 : 1962–1967.

Marshall I. WITHDRAWN: Zinc for the common cold. Cochrane Database Syst Rev 2007; (3): CD001364.

Meydani SN, Barnett JB, Dallal GE, et al: Serum Zinc and Pneumonia in Nursing Home Elderly. Am J Clin Nutr 2007; 86:1167.

Misbahuddin M, Islam AZ, Khandker S, et al: Efficacy of Spirulina Extract Plus Zinc in Patients of Chronic Arsenic Poisoning: A Randomized Placebo-Controlled Study. Clin Toxicol 2006; 44:135.

Mossad SB, Macknin ML, Medendorp SV et al: Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125: 81–88.

Murakami Y, Koyabu T, Kawashim A, et al: Zinc Supplementation Prevents the Increase of Transaminase in Chronic Hepatitis C Patients During Combination Therapy With Pegylated Interferon Alpha-2b and Ribavirin. J Nutr Sci Vitaminol 2007; 53:213.

Overbeck S, Rink L, Haase H: Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases. Arch Immunol Ther Exp 2008; 56 : 15–30.

Prasad AS, Fitzgerald JT, Bao B et al: Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 2000; 133: 245–252.

Prasad AS, Beck FW, Bao B, et al: Zinc Supplementation Decreases Incidence of Infections in the Elderly: Effect of Zinc on Generation of Cytokines and Oxidative Stress. Am J Clin Nutr 2007; 85:837.

Roldan S, Winkel EG, Herrera D, et al: The Effects of a New Mouthrinse Containing Chlorhexidine, Cetylpyridinium Chloride and Zinc Lactate on the Microflora of Oral Halitosis Patients: A Dual-Centre, Double-Blind Placebo-Controlled Study. J Clin Periodontol 2003; 30:427.

Shankar AH, Genton B, Baisor M, et al: The Influence of Zinc Supplementation on Morbidity Due to Plasmodium falciparum: A Randomized Trial in Preschool Children in Papua New Guinea. Am J Trop Med Hyg 2000; 62:663.

Simasek M, Blandino DA: Treatment of the common cold. Am Fam Physician 2007; 75 : 515–520.

Smith W, Mitchell P, Webb K et al: Dietary antioxidants and age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology 1999; 106 : 761–767.

Tipton K, Green NR, Haymes EM et al: Zinc loss in sweat of athletes exercising in hot and neutral temperatures. Int J Sport Nutr 1993; 3: 261–271.

Kursübergreifende Literaturangaben zu Vitaminen und Spurenelementen

Biesalski HK, Biscoff SC, Puchstein C. Ernährungsmedizin. Nach dem neuen Curriculum Ernährungsmedizin der Bundesärztekammer. 4. Auflage. Georg Thieme Verlag, Stuttgart 2010

Bundesinstitut für gesundheitllichen Verbraucherschutz und Veterinärmedizin. Toxikologische und ernährungsphysiologische Aspekte der Verwendung von Mineralstoffen und Vitaminen in Lebensmitteln. Teil I: Mineralstoffe (einschließlich Spurenelemente). Vorschläge für Regelungen und Höchstmengen zum Schutz des Verbrauchers vor Überdosierung beim Verzehr von Nahrungsergänzungsmitteln (NEM) und angereicherten Lebensmitteln. Januar 2002.

Cliniguía. Actualización de diagnóstico y terapéutica. EviScience Publicaciones 2011

Colastra J: Lamberts. Manual de Nutrición Ortomolecular. El manual de consulta imprescindible. SIE Consultants sl 2010

D-A-CH, Deutsche Gesellschaft für Ernährung (DGE), Österreichische Gesellschaft für Ernährung (ÖGE), Schweizerische Gesellschaft für Ernährung (SGE), Schweizerische Vereinigung für Ernährung (SVE): Referenzwerte für die Nährstoffzufuhr. Umschau Braus GmbH, Verlagsgesellschaft, Frankfurt am Main, 2008.

D-A-CH (2000) Deutsche Gesellschaft für Ernährung (DGE), Österreichische Gesellschaft für Ernährung (ÖGE), Schweizerische Gesellschaft für Ernährungsforschung (SGE), Schweizerische Vereinigung für Ernährung (SVE): Referenzwerte für die Nährstoffzufuhr. 1. Auflage, Umschau/Braus Verlag, Frankfurt am Main.

Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung: Referenzwerte für die Nährstoffzufuhr. 1. Auflage, 5., korrigierter Nachdruck, Neuer Umschau Buchverlag, Neustadt an der Weinstraße, 2013.

Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung: Referenzwerte für die Nährstoffzufuhr. Verfügbar unter: https://www.dge.de/wissenschaft/referenzwerte/ (eingesehen am 07.07.2021)

Dietl H., Ohlenschläger G. (2003) Handbuch der Orthomolekularen Medizin. Karl F. Haug Verlag, Stuttgart

Domke A, Großklaus R, Niemann B, Przyrembel H, Richter K, Schmidt E, Weißenborn A, Wörner B, Ziegenhagen R: Verwendung von Mineralstoffen in Lebensmitteln. Toxikologische und ernährungsphysiologische Aspekte Teil II Bundesinstitut für Risikobewertung. Verfügbar unter: http://www.bfr.bund.de/cm/350/verwendung_von_mineralstoffen_in_lebensmitteln_bfr_wissenschaft_4_2004.pdf (eingesehen am 07.07.2021)

Einkaufs-und Ernährungsverhalten in Deutschland TNS-Emnid-Umfrage des Bundesministerium für Ernährung und Landwirtschaft, BMEL, (2014). Verfügbar unter: https://www.bmel.de/SharedDocs/Downloads/DE/_Ernaehrung/Lebensmittel-Kennzeichnung/TNS-Emnid-EinkaufsErnaehrungsVerhaltenInDeutschland.pdf?__blob=publicationFile&v=2 (eingesehen am 07.07.2021)

Europäische Richtlinie (2008/100/EG) vom 28. Oktober 2008 über die Nährwertkennzeichnung von Lebensmitteln hinsichtlich der empfohlenen Tagesdosen, der Umrechnungsfaktoren für den Energiewert und der Definitionen online verfügbar unter: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:32008L0100:DE:HTML (eingesehen am 07.07.2021)

Europäische Empfehlungen: European Micronutrient Recommendations Aligned (EURRECA). Verfügbar unter: http://www.eufic.org/en/collaboration/article/european-micronutrient-recommendations-aligned (eingesehen am 07.07.2021)

Food and Nutrtition Information Center der US Regierung (DRI-Empfehlungen). Verfügbar unter: https://www.nal.usda.gov/fnic/dri-nutrient-reports (eingesehen am 07.07.2021)

Food Standards Agency (2002) Expert Group on Vitamins and Minerals. Review of Molybdenum.

Food Standards Agency (2003) Safe Upper Levels for Vitamins and Minerals. Expert Group on Vitamins and Minerals, May 2003

Gröber U: Orthomolekulare Medizin. Ein Leitfaden für Apotheker und Ärzte. 3. Auflage. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart 2008

Heppe F, Wigand M: Lexikon Diätetische Indikationen. Spezielle Ernährungstherapie und Ernährungsprävention. 4. Auflage. Springer 2002

Hernandez Ramos F: Antienvejecimiento con nutrición ortomolecular. Integral 2007

Institute of Medicine: Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. National Academy Press, Washington, 2001.

Koula-Jenik H, Kraft M, Miko M, Schulz RJ: Leitfaden Ernährungsmedizin. Urban & Fischer 2006

Otten JJ, Pitzi-Hellwig J, Meyers L (Eds): Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. The National Academies Press, Washington DC 2006.

Richtlinie der European Food Safety Authority, EFSA, mit dem Titel „Scientific Committee on Food, Scientific Panel on Dietetic Products, Nutrition and Allergies: tolerable Upper Intake Levels for Vitamins and minerals. February 2006“. V

Subcommittee on the Tenth Edition of the RDAs, Food and Nutrition Board, Commission on Life Sciences, National Research Council: Recommended Dietary Allowances: 10th Edition. National Academy Press, Washington DC, 1989.

Vollwertig essen und trinken nach den 10 Regeln der DGE verfügbar unter: http://www.dge.de/modules.php?name=Content&pa=showpage&pid=15 (eingesehen am 07.07.2021)

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